Carboxyhemoglobin Determination in The Sternum Red Marrow at Lethal Carbon Monoxide Poisoning

1Danchenko E.O., 2Al -Turki A., 3Tetyuev A.M.,

1Forensic chemistry department of the State Committee of legal expertise of the Republic of Belarus in the Vitebsk region, 2Department of Forensic Medicine in Faculty of medicine, Sana`a university, 3Department of Forensic Medicine of the Vitebsk State Medical University)

Introduction:

Examination of fatal carbon monoxide poisoning remains an actual problem of Forensic Medicine. In the Republic of Belarus carbon monoxide (CO) poisoning, including combined intoxication with CO and ethyl alcohol, is about 15-20 % of all poisonings, and about 5% of all violent deaths.Quantitative detection of carboxyhemoglobin (COHb) in corpse blood has so far been used in forensic practice for the diagnosis of fatal CO poisoning. It is evident that blood COHb level may be affected by a number of factors: individual human body characteristics, diseases, injuries, alcohol intoxication, possibility of post-mortem penetration of CO and formation of carboxyhemoglobin in blood and organs of corpse, and the effect of heating [1–3].

There are conflicting data in literature regarding the effect of heating on blood carboxyhemoglobin.
Several authors [4, 5] using practical and experimental data revealed a direct correlation between CoHb and degree of body area damaged by flame. It is proved that CoHb decreases until its complete disappearance in blood tissue when exposed to heating, particularly an open flame [4]. Ageeva N.M. et al. [5] found that heat causes CoHb breakdown. They found that blood heating at 50-70°C with exposure of 10 to 30 minutes results in carboxyhemoglobin decrease by 3-60%, while heating at 80-100°C showed CoHb drop down to its minimum level, or it can't be detected at all.
According to Yamamoto K. et al. [3], blood HbCO decrease in corpse after heating results from hemoglobin CO elimination and its partial volatilization.

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