Assessment of Zinc and Copper Levels in Patients with Different Causes of Liver Cirrhosis

 Munira A Dughish1*, Mansour Al-Amrani2, Hanan Noman3

1Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, Sana’a University; 2Department of Medicine, Faculty of Medicine and Health Sciences, Sana’a University; 3Medical Laboratory Department, Hodeida University


Liver cirrhosis is a worldwide health problem in general and in Yemen in particular, mainly due to the environmental and nutritional health problems that lead to many liver diseases. Liver cirrhosis is the end stage of liver fibrosis. It is characterized by nodule formation1. It is commonly associated with abnormalities in the systemic circulation and impaired primary hemostasis2. Cirrhosis is a slowly progressing disease in which healthy liver tissues are replaced with scar tissues. This change in liver structure prevents the liver from carrying out its proper functions, and disturbances in the antioxidant system and oxidative stress may play a role in the pathogenesis of

chronic liver diseases3,4. However, Cirrhosis often is a silent disease, with most patients remaining asymptomatic until decompensating occurs. Quantity and duration of alcohol consumption is an important factor in the early diagnosis of cirrhosis3. Other risk factors include those for hepatitis B and C transmission, as well as transfusion history and personal or family history of autoimmune or hepatic diseases3,4. Liver plays a central role in zinc homeostasis, removing zinc from albumin in blood and distributing it to the body as needed. Hormonal stimuli such as glucocorticoids and epinephrine up-regulate hepatic zinc uptake by hepatic Metallothionein levels5,6. Zinc is an essential trace

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