Introduction:

Infertility is defined as inability to conceive after 1 year of un-protective intercourse1,2 Pregnancy represents the successful and timely conclusion of series of physiological events: ovulation of a mature oocyte, production of viable sperm, association of oocyte and sperm in the reproductive tract, making of a viable embryo, embryo carriage into the uterine cavity, and embryo implantation within the endometrial cavity. Any disruption in these essential steps will lead to infertility [3, 4]. Secondary infertility is defined as the inability to become pregnant, or to carry a pregnancy to term, following the birth of one or more biological children [3]. About 30% of the infertile cases

are solely attributed to the male partner, 30% to female partner, 25% of cases are caused by a combination of male and female factors and about 15% unexplained infertility [5, 6]. Most of the infertility treatments are dependent on the underlying cause of infertility [7]. Some infertile couples nevertheless need more complex medical intervention like ARTs which is referred to many methods designed to overcome barriers to natural fertilization [8]. Over all, the estimated number of infertile patients treated by ART is around 20%. The goal is to increase the success rate of ART both in term of achieving pregnancy and in making sure that the pregnancy result in a genetically healthy individual [9]. The duration of