Does Viral Hepatitis Attribute to Hepatocellular Carcinoma?

 Ahmed M.T. Al-Gharati1*, Murad A.A. Mukbel1, Mohamed A. Al-Haimi1, Mohamed S.A. Ghanem1

epartment of Internal Medicine, Faculty of Medicine and Health Sciences, Sana’a University – Sana’a

Introduction:

Hepatocellular carcinoma (HCC) is considered one of the most important malignant diseases today as it is the third most common causes of death from cancer and the most common complication of cirrhosis1. Cirrhosis is most often a result of chronic hepatitis B (HBV) and C (HCV) infection. HBV and HCV have been considered a worldwide health problem with approximately 75% to 80% of HCC cases are attributed to HBV and HCV2,3 . Studies conducted in different countries suggested a strong link between HBV infection and development of HCC4-18. HBV reported to be one of the most common human carcinogens according to World Health Organization19. The prevalence of HBV and HCV related HCC varies

greatly among different geographic regions, HCC caused by HBV is more prevalent in Asian countries excluding Japan, while HCV has been reported to be the most common underlying etiology of HCC in western European and North American countries. Epidemiological studies conducted in western European and North American countries, suggested that up to 70% of patients with HCC have anti-HCV antibody in the serum 18,20,21. Egypt has the highest prevalence of HCV in the world (predominantly genotype 4), which has been attributed to previous public health eradication schemes for Schistosomiasis. HBV and HCV in Yemen found to be important causes of chronic liver disease and cirrhosis22-28. In the studies conducted in eighties and nineties in the

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