Consanguinity is Strongly Associated with Fetal Congenital Anencephaly

Alia A Shuaib1*, Abdelrahman H Al Harazi1

1Department of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Sana’a University.

SUJMS • 2020 | Jan-Dec | Vol 14| Issue (1+2)

Introduction:


Consanguineous marriages refer to union contracted between biologically related couples1. Consanguinity is traditionally favored in most of the Eastern Mediterranean region, south Asia and African countries especially in the Muslim populations 2,3. It is reported that the overall consanguinity rates in such communities collectively account for 20-50% 4,1.

Corresponding Author: Alia A Shuaib, Department of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Sana’a University, Yemen The rate in Yemen is 40-44.7% 5 and similar to Qatar and Oman, the rates are increasing in the current generation 1 . In these countries inbreeding is popular and frequently respected practice1 because the religious, social and

cultural factors are still playing in favoring consanguineous union1. It is well known that offspring of consanguineous marriages are at increased risk for rare recessive syndrome, congenital malformation and fetal, infant and child morbidity and mortality 6-7 .

The detrimental health effects associated with consanguinity are caused by the expression of recessive genes inherited from a common ancestors which probably applies to rare single gene conditions as well as to multigenes disorders with multifactorial inheritance 8,9 .

Many different types of genetic disorders have been reported to be more common among consanguineous progeny such as neural tube defects (NTD) 10,8 including anencephaly which represents the most severe form of NTD 11-12 ..

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An Academic Biannual Refereed Journal, Published by Sana'a University

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