The diagnostic value of anti-mullerian hormone and follicular stimulating hormone in polycystic ovary syndrome patients

Ekram Al-Eryani 1*, Nadal Numan 1, Waled Al-Dubai 1, Twfik Al-Busaili 2

1 Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, University of Sana`a, Sana`a, Yemen;

2 Department of Obstetrics & Gynecology, Faculty of Medicine and Health Sciences, University of Sana’a, Yemen

SUJMS • 2021 | Dec | Vol 15| Issue. (2)

Introduction:

(FSH) [10]. The level of AMH can reflect the number of ovarian antrum follicles, ovarian reserve, and ovarian function [11]. Serum AMH is not affected by menstrual cycle and oral contraceptive use, so it has potential as a marker for the diagnosis of PCOS [12]. Studies have shown that the level of circulating AMH is two- to threefold higher in women with PCOS than in healthy women of childbearing age, probably due to increased follicular mass associated with PCOS [8,9]. In view of the fact that the increase in AMH levels has been reported to be associated with PCOS as well as long-term effect pf PCOS, the aim of this study was to explore the diagnostic value of AMH and other hormones in Yemeni patients with PCOS.

Materials and Methods

The study was a comparative cross–sectional study that was carried out on 80 women aged 18-50 years: 40 were healthy women with non-polycystic ovary syndrome serving as control group and 40 were patients with PCOS attending the University of Science and Technology Hospital and C-Pluse Hospital in Sanaa city for infertility evaluation during the period from September 2015 to February 2016.

aPCOS was diagnosed based clinical and biochemical signs of hyperandrogenism (HA); and presence of polycystic ovaries (PCOs), defined as the presence of ≥ 12 follicles measuring 2-9 mm in diameter in each ovary and/or increased ovarian volume (> 10 ml). The exclusion criteria were as follows: Cushing's syndrome, dysfunctional uterine bleeding, primary amenorrhea, adrenal cortical hyperplasia or tumor, thyroid dysfunction. The study protocol was approved by the institutional review board (IRB) of the Faculty of Medicine and Health Sciences, Sana’a University. Informed consent form was obtained from all individuals after explaining the purpose and nature of the study. The patients’ height and weight were measured and body mass index (BMI), defined as weight (kg)/ height squared (m2), was calculated. Standardized questionnaire(s) was administered to collect participants’ demographic and

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