Waled A. Al-Dubai 1*, Jameel A. Al-Ghazaly2, Sami S. Al-Dubai3, Najlaa Z. Amer1
1 Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, Sana’a University, Sana'a, Yemen
2 Department of Internal Medicine, Faculty of Medicine and Health Sciences, Sana’a University, Sana'a, Yemen 3 Aulaqui Specialized Medical Laboratories, Sana'a, Yemen.
SUJMS • 2021 | Jane | Vol 15| Issue. (1))
Down syndrome (DS), or trisomy 21, represents the most common chromosomal abnormality associated with intellectual impairment . Down syndrome is the most common chromosomal disorder with prevalence estimates ranging from 6.1 to 13.1 per 10,000 people [2,3]. Most often DS results from complete trisomy of chromosome 21, due to non-disjunction during gamete formation (about 95%), while the remaining ones are due to either complete or partial translocation of chromosome 21 to another chromosome, typically in the D (13–15) or G (21–22)