New Topical Pharmaceutical Formulations of Econazole& their Evaluation

Sabati A. M, and Othman A. M.

Department of Pharmaceutics, Faculty of Pharmacy, Sana’a University, Yemen.


Econazole nitrate is an antifungal drug, it’s a member of azole class, it is interfering with fungal oxidative enzyme to cause lethal accumulation of hydrogen peroxides, also reduce the formation of ergosterol by interact with C-14 alpha-demethylase (cytochrome
P450 enzyme) to block demethylation of lanosterol to ergosterol, the inhibition will disrupt membrane function & increase permeability to intra cellular constituents I -
Econazole nitrate is effective against candida spp, blastomyces dermatitidis coccidioides immitis, cryptococcus neformans, histoplasma capsulatum, paracoccidioids
brasiliensis, Malessezia furfur, Aspergillus spp, sporothrix schenckii, most dermatophytes including epidermophyton floccosum, microsporum canis trichophyton mentography, trichophyton rubrum and

some gram-positive bacteria including staphylococcus, streptococcus and nocardia
Econazole weakly absorbed orally, that the mean peak plasma concentration was 2.6μg/ml 2.5hours after oral administration of 250mg of econazole, about 40% of the oral dose administered is exerted in the urine and 30% was eliminated in the faeces.
Econazole is widely distributed to body tissues, particularly the joints, skin and eyes but don’t penetrate CSF, absorption of econazole nitrate is not significant when applied topically (10% is absorbed after topical application to the skin and 5% after vaginal application.3,8
Econazole nitrate is applied topically as a 1% cream, lotion, powder or solution in the treatment of fungal infections such as candidiasis, tinea and pityriasis versicolor. Econazole nitrate has also been administered

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