Introduction:

Hodgkin's disease has been traditionally used for a type of malignant lymphoma in which Reed -Sternberg cells are present in a background of reactive inflammatory cells of various types accompanied by fibrosis of variable degree1. The first detailed account of Hodgkin's disease originating primarily in the organs of lymphoreticular system was given in 1832 by Thomas Hodgkin that was later to bear his name2. Because of its inflammatory histological appearance and the variable distribution of
Reed-Sternberg cells, Hodgkin's disease usually lacks the histologic monotony that is characteristic of most of non-Hodgkin's lymphomas and others neoplasms3. The finding of Reed-Sternberg cells and their morphologic variant (collectively termed Reed-Sternberg cells) in the appropriate histological setting

is a corner stone for the diagnosis of Hodgkin's disease4.
Methodology:
A descriptive record based study of 366 cases of Hodgkin's disease was carried out in the department of pathology, Faculty of Medicine and Health Science, Sana'a University during the period from 1st January 2004 to the 30th December 2007. The diagnosis were made primarily on private laboratories of three well-known pathologist in Sana'a who received the histopathologic biopsies from Sana'a and and the other Yemeni provinces. The biopsies of the tissue effected were fixed in 10% formalin solution before being processed by manual and automatic tissue processor. After embedding in paraffin blocks several thin sections of 2 to 3 micrometer thickness from each block were cut. The sections were stained with