SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NEW N-R-OXAMOYLAMINO ACID DERIVATIVES AND THEIR SALTS OF 2-ETHOXY-6,9-DIAMINOACRIDINE.

Al-Rahawi K.M1; Al-Kaf A.G.2

1,2Medicinal chemistry department, Faculty of Pharmacy, Sana’a University (Yemen)

INTRODUCTION:

Oxamoylamino acids is a new group of biological active compounds , study of this chemical group was started recently after elaboration of method of it’s synthesis[1,2].
It was shown, that the representatives of this group exhibit broad biological activity anti- inflammatory antialergic, nооtropic, local anaesthetic, antioxidant hepatoprotector,
antimicrobial, antiviral and others [2-7].
The purpose of this work was to synthesize new N-R-oxamoylaminoacids, their salts, and to study their antimicrobial activity.

Synthesis of the targeted compounds have been carried out as described by the following scheme:

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An Academic Biannual Refereed Journal, Published by Sana'a University

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